Time to Achieve Steady State

The time required to reach steady state is dependent on the drug half-life. It takes 5-6 half-lives to reach steady state.

Half life (hr)
S.S.
S.S.
S.S.

The longer the half-life, the longer it takes to reach steady state.

When different doses are administered, the steady state concentrations will be proportional to the dose, but the time to reach steady state will be independent of the dose.

Dose (mg)
S.S.
S.S.
S.S.
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