Factors Affecting Steady State Concentration

a- Dose

Examine the conc-time profile after administration of different doses, while keeping all other parameters constant.

Parameters
D (mg) F CLΤ(L/hr) Vd (L) ka (hr-1)
800 1 7.5 50 0.3
Dose (mg) q 8 hr

The steady state plasma concentartion is proportional to the administered dose