Questions

During repeated administration of 60 mg indomethacin tablet every 12 hours (F=1) for the treatment of rheumatoid arthritis the AUC during one dosing interval was 18 mg-hr/L. What is the average indomethacin steady state plasma concentration during this dosing regimen (60 mg every 12 hours) ?

1 - 2 mg/L 2 - 7.5 mg/L 3 - 5 mg/L 4 - 1.5 mg/L