Questions

A patient is taking 200 mg quinidine sulfate tablet every 8 hours for the treatment of cardiac arrhythmia. His average plasma quinidine concentration at steady state was 2 mg/L. Because the patient condition was not controlled, the physician asked you to recommend a dosing regimen that will increase the average steady state plasma quinidine concentration in this patient to 6 mg/L. What will be your recommendation?

1 - 200 mg every 12 hours 2 - 300 mg every 8 hours 3 - 600 mg every 8 hours 4 - 400 mg every 12 hours