Questions

Naproxen is a nonsteroidal antiinflammatory drug used in the treatment of rheumatoid arthritis. Its elimination rate constant is 0.05 hr-1 and its volume of distribution is 0.17 L/kg. What will be the dosing regimen required for a 60-kg man to achieve an average plasma concentration of 50 mg/L at steady state ? (bioavailability is 100%)

1 - 100 mg every 8 hours 2 - 300 mg every 12 hours 3 - 500 mg every 8 hours 4 - 300 mg every 6 hours