Questions

A patient was taking 50 mg of propranolol every 12 hours to control his hypertension. The patient developed acute liver failure, and his physician was worried because the liver is the major organ responsible for propranolol elimination. What will happen if the patient continue taking his 50 mg every 12 hours propranolol tables?

1 - Propranolol clearance will be higher and s.s. conc will be lower 2 - Propranolol clearance will be lower and s.s. conc will be lower 3 - Propranolol clearance will be lower and s.s. conc will be higher 4 - Propranolol clearance will be higher and s.s. conc will be higher