Larger Vmax results in higher total body clearance and faster rate of drug elimination. After multiple administration of similar doses, the steady state conc will be lower when Vmax is higher.
Doseis the administered dose of the drug (amount).
Vmaxis the maximum rate of drug metabolism (amount/time). In this example it is also the maximum rate of drug elimination since it is assumed that the drug is eliminated via a single pathway.
Kmis the Michaelis-Menten constant. It is the substrate concentration when the rate of the reaction is equal to half Vmax (amount/volume).
Vmax
In enzyme kinetics Vmax is the maximum rate of the enzymatic reaction. For drug metabolism in vivo, Vmax is the maximum rate of drug metabolism by a specific pathway.Vmax has units of amount per time and can also have units of concentration per time.
The maximum rate of drug metabolism is dependent on the amount of enzyme available for drug metabolism via a specific pathway. Enzyme induction results in increasing the amount of the enzyme and Vmax.
Diseases that affect the liver (the primary organ for drug metabolism) may result in decreasing the metabolic capacity for metabolic pathways and decreases Vmax. Also, Vmax may depend on the size of the patient. Children may have lower Vmax compared to adults.
