Dose :  The administered dose, mg

F :  The drug bioavailability, no units

Dosing interval :  The time between doses, hours

k_a :  The first order absorption rate constant, hour ^-1

Vd :  The volume of distribution, liters

k_m :  Michaelis-Menten constant, mg/L

V_max :  Maximum rate of drug elimination, mg/hr

Cp :  Drug concentration in the systemic circulation, mg/L