Pharmacokinetic Model

F Dose

GIT

ka

Systemic
Circulation

Vmax Cp

Km + Cp
(Vd)
  • Dose :  The administered dose, mg

  • F :  The drug bioavailability, no units

  • Dosing interval :  The time between doses, hours

  • ka :  The first order absorption rate constant, hour -1

  • Vd :  The volume of distribution, liters

  • km :  Michaelis-Menten constant, mg/L

  • Vmax :  Maximum rate of drug elimination, mg/hr

  • Cp :  Drug concentration in the systemic circulation, mg/L