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- Module
19- Nonlinear pharmacokinetics - Introduction to pharmacokinetics
- IV administration
- Oral administration
- Steady state concept
- Drug elimination
- Drug pharmacokinetics in renal dysfunction
- Multiple compartment pharmacokinetics
- Nonlinear pharmacokinetics
- Intermittent IV infusions
- Physiological approach to the clearance concept
- Kinetics of the pharmacological effects
- Therapeutic drug monitoring
- Objective
- Introduction
- Introduction
- Michaelis-Menten kinetics
- Factors affecting the plasma concentration-time profile Dose, Vmax, and Km
- Oral drug administration
- Determination of the Michaelis-Menten pharmacokinetic parameters
- Mathematical method
- Direct linear plot
- Linear transformation method
- Other causes of nonlinear pharmacokinetics
- Summary
- Plot
- Questions