Factors affecting the plasma conc-time profile

a- Dose

Examine the conc-time profiles after administration of different doses when Km and Vmax are similar.

Parameters
Dose (mg) Vmax (mg/hr) Km(mg/L)
2000 60 10
Dose(mg)

Larger doses achieve higher initial drug conc. Higher conc results in lower clearance and longer half life. However at any conc, the rate of decline of the drug conc is similar, since Km and Vmax are constant.

Parameters
Dose (mg) Vmax (mg/hr) Km(mg/L)
100 35 8
Dose(mg)

Increasing the dose results in more than proportional increase in the steady state conc. It takes longer time to achieve steady state when larger doses are administered.

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