Example: Ampicillin CLT is 10 L/hr, and its renal clearance is 80% of the CLT. Probenecid is given in combination with ampicillin to inhibit its renal elimination and to achieve higher plasma and tissue antibiotic conc in the treatment of Neisseria Gonorrhoeae. If probenecid decreases the renal clearance of ampicillin by 50% without affecting its nonrenal clearance, calculate ampicillin CLT and fraction of dose excreted in urine when given with probenecid.

Ampicillin CLT when given with probenecid

Renal clearance = 4 L/hr,
and total body clearance = 6 L/hr

Answer

When ampicillin is given with probenecid:

CLT = 2 L/hr + 4 L/hr = 6 L/hr

Fraction = CLR/CLT

Fraction of dose excreted in urine = 0.667

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