The drug conc at any time after a single iv administration of a drug that follows two-compartment pharmacokinetic model can be described by the following expression:
The plasma concentration declines biexponentially
Distribution Phase
Elimination Phase
Distribution Phase
Elimination Phase
Initially the curve describes simultaneous distribution and elimination.
The terminal part of the curve represents drug elimination.
The plasma concentrations measured after a single iv administration can be used to calculate the pharmacokinetic parameters (A, B, α, and β ). These parameters can be used to solve for all other parameters. The pharmacokinetic parameters allow prediction of the conc during repeated drug administration and the dose required to achieve specific conc.
