It is important to determine if the drug follows one- or two-compartment model for accurate estimation of the elimination and all other parameters.
a- The elimination half life will be under-estimated if the samples were taken over a short period of time during the distribution phase. The estimated half life will be significantly shorter than the actual half life
Estimated elimination half life
Estimated elimination half life
Actual elimination half life
b- The elimination half-life will also be underestimated if the samples are taken over long time but the elimination half life is estimated based on one-compartment pharmacokinetic model.
Estimated elimination half life
Estimated elimination half life
Actual elimination half life
Accurate estimation of the elimination half life is necessary for individualization of dosage regimens and dosage adjustment.
