The volume of distribution is the parameter that relates the amount of the drug in the body to the drug concentration in the sampling compartment.
Different drugs have in the same patient.
Different for the same drug.
Consider the following example:
When a dye is added to a beaker filled with a solvent, the dye will dissolve in the solvent. The resulting concentration will depend on:
1- The amount of dye
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When different amount of the dye is added to the same volume, larger amount will produce higher concentration
1- The volume of the beaker
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When same amount of the dye is added to different volumes, smaller volume will produce higher concentration
From the previous example:
If you want to determine the volume of a solvent inside a beaker:
a - Add an accurately measured amount of a dye to the solvent
b - Measure the concentration of the dye in the beaker
In this example we calculated the actual physical volume of the solvent in the beaker
