Pharmacokinetic Model

Iv bolus

(Dose)

Systemic Circulation

(Vd)

k

  • Dose : The administered dose, mg

  • Vd : The volume of distribution, liters

  • k = CLT/Vd : The first order elimination rate constant, hour-1

Assume that a single 100 mg iv bolus dose of a drug that has total body clearance of 6.0 L/hr is administered. Choose different values for the volume of distribution and simulate the corresponding drug concentration-time profiles.