Questions

Theophylline has Vd of 0.45 L/kg, and elimination rate constant of 0.11 hr-1, while ampicilline has Vd of 0.3 L/kg and elimination rate constant of 0.6 hr-1. After iv administration of equal doses of these two drugs, which of the following statements is correct ?

1 - Ampicilline plasma cone will always be higher than those of theophylline 2 - Initial theophylline plasma cone > initial ampicilline plasma conc 3 - Theophylline is eliminated faster than ampicilline 4 - Initial ampicilline plasma cone > initial theophylline plasma conc