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This is an exercise to simulate how the change in the volume of distribution affects the plasma concentration-time profile after a single iv administration, if the dose and the total body clearance were kept constant.

You are asked to select a value for the volume of distribution and then click plot to simulate the plasma concentration-time profile after administration of a single 100 mg iv dose, assuming that the total body clearance is 6 L/hr.

You can adjust the values for the X and Y axes to see the entire plot by clicking the adjust x scale or adjust y scale buttons.