Determination of the Pharmacokinetic Parameters

The plasma drug concentration increases during the constant rate iv infusion, until steady state is achieved.

Steady State

Slope = -k/2.303

CLT

Vd
= k

a- The total body clearance:

The CLT can be determined from the steady state conc and the infusion rate.

CLT =

K0

Cps.s.

b- The elimination rate constant can be determined only after termination of the infusion from the slope of the resulting line.

c- The volume of distribution is calculated from the CLT and k.

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