Pharmacokinetic Model

Loading dose + Ko

IV bolus +IV Infusion)

Systemic Circulation

(Vd)

k

  • Ko : The drug infusion rate, mg/hr

  • Loading dose : A single iv bolus dose administered before the start of the iv infusion, mg

  • Vd : The volume of distribution, liters

  • k = CLT/Vd : The first order elimination rate constant, hour-1