Objectives

After completing this module you should be able to:

• Define the steady state during constant rate iv infusion.

• Identify the factors that affect the steady state plasma concentration during constant rate iv infusion.

• Determine the steady state drug concentrations and the pharmacokinetic parameters during constant rate iv infusion.

• Analyze the effect of changing one or more of the pharmacokinetic parameters on the steady state plasma concentration during constant rate iv infusion.

• Recommend an appropriate iv loading dose and iv infusion rate to achieve specific steady state plasma concentration.

• Evalute the appropriateness of certain infusion rates in specific patients.