Time to Achieve Steady State

The time required to achieve steady state is dependent on the drug half-life It takes 5-6 half-lives to reach steady state.

Half Life (hr)
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The longer the half-life, the longer it takes to reach steady state.

When the same drug is administered by different infusion rates, the steady state concentrations will be proportional to the infusion rate, however the time to reach steady state will be independent of the infusion rate.

inf. rate (mg/hr)
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