Steady State Conc during IV Infusion

b- Volume of distribution

Examine the steady state conc during administration of the same iv infusion rate of different drugs that have the same CLT but different Vd.

Parameters
K0 (mg/hr) CLΤ(L/hr) Vd (L)
50 6 15
Vd (L)

The volume of distribution does not affect the steady state conc. The steady state conc is only dependent on the total body clearance and the infusion rate (K0).

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