Example: What is the theophylline steady state conc during a constant rate iv infusion of 30 mg/hr theophylline ? and what is the rate of theophylline elimination at steady state ? (Theophylline Vd is 30 liters and k is 0.1155 hr-1)

Cps.s. =

K0

CLT

30 mg/hr

Cps.s. =

30 mg /hr

0.1155hr-1 30L =8.66 mg/L

At steady state, the administration rate is equal to the elimination rate. So, theophylline elimination rate at steady state is 30 mg/hr.

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