A general anesthetic has Vd of 2 L/kg, k of 0.3 hr -1, and minimum effective concentration of 1 mg/L (this means that the drug is effective as long as the plasma concentration is above 1 mg/L). What is the expected duration of effect after administration of a single iv dose of 5 mg/kg?
Cp0 =
Dose
Vd = 5mg/kg
2L/kg = 2.5mg/L
1mg/L =
2.5mg/L e-0.3hr-1t
(duration of effect) t =
3.03hr
The idea is to find the length of time during which the drug concentration is above 1 mg/L.
2.5 (mg/L)
MEC
1mg/L
Duration of effect
