Factors affecting drug pharmacokinetics
in renal dysfunction (cont'd)

c- Dose

Examine the drug conc-time profiles after administration of different doses of a drug to a patient with reduced kidney function. All other parameters are kept constant

Parameters
D (mg) KF f
100 .5 .5
Dose
CLT = 3 L/hr
ka = 0.5 hr-1
Vd = 20 L

Detailed conclusion

Administration of higher doses results in a proportional increase in the steady state drug concentrations.