When a second dose of the drug is administered as a short infusion:
Conc resulting from the new dose
Conc left from the previous dose
Notice that the increase in drug
conc due to administration of
the same dose over the same
period of time is constant.
The plasma conc at the end of the second dose will be the sum of the conc resulting from the new dose and the conc remaining from the previous dose.
where Cpx is the drug conc just before drug administration.
Conc resulting from the new dose
Conc left from the previous dose
Cpx
This is the general expression that describes
the plasma conc for drug administration as
short constant iv infusion.
The drug conc at any time after the end of drug administration can be described by:
