Drug concentration-time profile (cont'd)

Following repeated drug administration every (τ), steady state is achieved:

Cpmax ss
Cpmin ss
Ko is the drug infusion rate. It is equal
to the dose divided by the infusion rate
(Ko = Dose/t')

The conc right after drug administration is Cpmax and the conc just before drug administration is Cpmin.

At steady state :

Cp max ss =

K0

k Vd ( 1 - e-kt' )+ Cpmin ss e-kt'

and

Cp min ss = Cp max ss e-k(τ-t')

This is because the time difference between Cpmax and Cpmin is (τ - t' ) :

Substituting for Cpmin ss:

Cpmax ss =

K0( 1 - e-kt' )

k Vd( 1 - e-kτ )
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