Metabolite Formation

The metabolite AUC after administration of a single iv dose of a drug is dependent on the amount of the metabolite formed and the total body clearance of the metabolite.

The maximum amount of the metabolite that can be formed after administration of the parent drug should not exceed the dose of the parent drug (in terms of molar amounts).

However, the metabolite AUC after administration of the parent drug can be smaller or larger than the parent drug AUC because the metabolite has its own CL_T(m).

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Metabolite Formation

Metabolite area under the curve ( AUC(m))

The metabolite total body clearance (CLT(m))

Area under the curve

Metabolite area under the curve ( AUC_(m))

The metabolite total body clearance (CL_T(m))