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- Module
13-Renal Excretion of drugs - Introduction to pharmacokinetics
- IV administration
- Oral administration
- Steady state concept
- Drug elimination
- Drug pharmacokinetics in renal dysfunction
- Multiple compartment pharmacokinetics
- Nonlinear pharmacokinetics
- Intermittent IV infusions
- Physiological approach to the clearance concept
- Kinetics of the pharmacological effects
- Therapeutic drug monitoring
- Objective
- Introduction
- Introduction
- A simple model for metabolite kinetics
- Metabolite elimination
- A general model for metabolite kinetics
- Metabolite concentration-time profile
- Metabolite formation
- Determination of the metabolite pharmacokinetic parameters:
k(m), Vd(m), fm, and AUC(m) - Summary
- Plot
- Questions