Objectives

After completing this module, you should be able to

• Describe the pharmacokinetic processes involved in the formation and elimination of the metabolites after parent drug administration.

• Describe the simple and the general models that describe the formation of metabolites after administration of the parent drug.

• Define the mathematical expressions that describe the plasma conc-time profiles of the drug and its metabolite at any time after iv drug administration.

• Identify the factors that affect the metabolite formation after administration of the parent drug.

• Calculate the different metabolite pharmacokinetic parameters after iv administration of the parent drug.