Questions

After administration of codeine 10% of the dose is metabolized to morphine. Codeine Vd is 2.6 L/kg and k is 0.2 hr-1, while morphine Vd is 3.33 L/kg and k is 0.3 hr-1. What is the observed morphine AUC after administration of a single iv dose of 1 mg/kg codeine ?

1 - 0.10 mg-hr/L 2 - 0.19 mg-hr/L 3 - 1.00 mg-hr/L 4 - 1.90 mg-hr/L