b- Is an immediate effect required?
When an immediate drug effect is required administration of an appropriate loading dose will be necessary to achieve faster approach to .
Loading dose (mg)
MTC
MEC
Therapeutic drug concentrations are
achieved immediately after
administration of the loading dose.
c- Is the patient to receive a sustained release or a fast-release formulation.
Sustained release preparations produce little fluctuations in the plasma drug concentration, and fast-release preparation produce larger fluctuations in the plasma concentration during multiple administration.
Formulations that release the drug rapidly may need to be administered more frequently in smaller doses.
Periodic evaluation of the dosing regimen and the therapeutic effects is necessary when the patient disease state is not stable and when the response of the body to the drug changes with time.
