The dose required to achieve the desired maximum conc when given every (τ) can be determined from the following equation using the rounded dosing interval:
Again it may be necessary to round the calculated dose to the nearest available formulation strength.
iii- Selection of the loading dose
The loading dose is administered when an immediate drug effect is required, and it is calculated as:
Therapeutic
Range
MTC
MEC
}
Conclusion
The ideal dosing regimen should
maintain plasma drug conc within
the therapeutic range all the time.
