Effect of the change in CLint on the
plasma conc-time profile

1- Low extraction ratio drugs

a- IV administration

Examine the effect of increasing the CLint (due to enzyme induction) of a drug that is completely eliminated by the liver.

Parameters
D(mg) CLint (L/min) Q (L/min)
1000 .05 1.5
CLint(L/min)

Detailed Conclusions

The increase in intrinsic clearance results in (approximately) proportional increase in drug clearance and drug elimination rate.