Module
21- Physiological approach to hepatic drug clearance
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Objectives
Introduction
Introduction
Physiological approach to organ drug clearance
Extraction ratio and intrinsic clearance
Effect of blood flow and intrinsic clearance on the extraction ratio
Effect of the change in intrinsic clearance on the drug profile
Effect of the change in liver blood flow on the drug profile
Effect of plasma protein binding on drug elimination
Summary
Plot
Plot
Linear
Semilog
Help
Questions
×
Module
21- Physiological approach to hepatic drug clearance
Introduction to pharmacokinetics
IV administration
Elimination Rate Constant
Volume of Distribution
Half Life
Total Body Clearance
Area Under The Curve
IV Drug Administration
Oral administration
Bioavailability and bioequivalence
Absorption rate constant
Oral drug administration
Steady state concept
Constant rate infusion
Multiple Drug Administration
Drug elimination
Renal Excretion of Drugs
Metabolite kinetics (I)
Metabolite kinetics (II)
Drug pharmacokinetics in renal dysfunction
Multiple compartment pharmacokinetics
Two compartment pharmacokinetic model (I)
Two compartment pharmacokinetic model (II)
Nonlinear pharmacokinetics
Intermittent IV infusions
Physiological approach to the clearance concept
Kinetics of the pharmacological effects
Therapeutic drug monitoring
Objective
Introduction
Introduction
Physiological approach to organ drug clearance
Extraction ratio and intrinsic clearance
Effect of blood flow and intrinsic clearance on the extraction ratio
Effect of the change in intrinsic clearance on the drug profile
Effect of the change in liver blood flow on the drug profile
Effect of plasma protein binding on drug elimination
Summary
Plot
Plot
Linear
Semilog
Help
Questions
Which of the following drugs will be affected the most with changes in the plasma protein binding ?
1 -
Valproic acid (Low extraction ratio, 93% protein bound)
2 -
Lidocaine (high extraction ratio, 70% protein bound)
3 -
Theophylline (low extraction ratio, 55% protein bound)
4 -
Propranolol (high extraction ratio, 85% protein bound)