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- Module
21- Physiological approach to hepatic drug clearance - Introduction to pharmacokinetics
- IV administration
- Oral administration
- Steady state concept
- Drug elimination
- Drug pharmacokinetics in renal dysfunction
- Multiple compartment pharmacokinetics
- Nonlinear pharmacokinetics
- Intermittent IV infusions
- Physiological approach to the clearance concept
- Kinetics of the pharmacological effects
- Therapeutic drug monitoring
- Objective
- Introduction
- Introduction
- Physiological approach to organ drug clearance
- Extraction ratio and intrinsic clearance
- Effect of blood flow and intrinsic clearance on the extraction ratio
- Effect of the change in intrinsic clearance on the drug profile
- Effect of the change in liver blood flow on the drug profile
- Effect of plasma protein binding on drug elimination
- Summary
- Plot
- Questions