Effect of the change in liver blood flow
on the plasma conc-time profile

1- Low extraction ratio drugs

a- IV administration

Examine the effect of the change in liver blood flow on the elimination rate of a drug that is completely eliminated by the liver.

Parameters
D(mg) CLint (L/min) Q (L/min)
1000 .1 .5
Q (L/min)

Detailed Conclusions

The increase in liver blood flow causes insignificant change in the drug clearance and drug elimination rate.