Physiological approach to organ drug clearance

Consider an eliminating organ:

Rate in

Q.Cpa

Elimination organ

Rate out

Q.Cpv

Rate of elimination

The rate of drug reaching the organ is the product of organ blood flow (Q) and the concentration of the drug in the arterial blood (Cpa), and the rate of drug leaving the organ is the product of organ blood flow (Q) and the concentration of the drug in the venous blood (Cpv).

The rate of drug elimination is (rate in - rate out)

= Q . Cpa - Q . Cpv
= Q (Cpa - Cpv)
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