The physiological approach to organ clearance uses the organ capacity for drug elimination, organ blood flow, and protein binding to describe the rate of organ drug elimination and the drug profile in the body.

The organ clearance is defined as the volume of plasma or blood completely cleared from the drug per unit time by that particular organ.

The physiological approach allows prediction of the change in drug disposition due to alteration in organ blood flow, enzymatic activity, or protein binding.

This is important because the effect of diseases and pharmacokinetic drug-drug interactions on the overall drug disposition can be predicted.