Physiological approach to total body clearance (Cont'd)

Consider an eliminating organ:

Rate In

Q. Cpa

Eliminating organ

Rate of drug elimination

Rate out

Q. Cpv

The organ clearance can be determined from the drug elimination rate by the organ and the plasma drug concentration.

Clearance =

Q (Cpa - Cpv)

Cpa
Clearance = Q E
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