Total Body Clearance

Assuming first-order elimination, the rate of disappearance of the drug from the body after an iv dose is:

-

dA

dt =k A

where A is the amount of the drug in the body and it is equal to Cp Vd

-

dA

dt =k Cp Vd

by dividing both sides of the equation by Cp :

-

dA

dt

Cp

 =k Vd = CL T

This means that CLT can be determined from the drug elimination rate divided by the corresponding plasma concentration:

Drug excretion rate

Cp at the same time = CLT
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