Physiological approach to total body clearance

Consider an eliminating organ:

Rate In

Q. Cpa

Eliminating organ

Rate of drug elimination

Rate out

Q. Cpv

The rate of drug entering the organ is the product of organ blood flow (Q) and the concentration of the drug in the arterial blood (Cpa), and the rate of drug leaving the organ is the product of organ blood flow (Q) and the concentration of the drug in the venous blood (Cpv).

The rate of drug elimination = rate in - rate out

= Q . Cpa - Q . Cpv
= Q (Cpa - Cpv)
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