Pharmacokinetic Model

Iv bolus

(Dose 1000 mg)

Systemic Circulation

(Vd)

k

  • Dose : The administered dose, mg

  • Vd : The volume of distribution, liters

  • k = CLT/Vd : The first order elimination rate constant, hour-1

Choose different values for the total body clearance, then simulate the corresponding drug concentration-time profiles.

In this simulation the dose is 1000 mg and the volume of distribution is 12 Liters.