Total Body Clearance

After a single iv dose the amount of the drug in the body decreases with time.

Slope = -k/2.303

The rate of drug elimination decreases with time due to the decrease in drug amount in the body.

-

dA

dt
=k A

A plot of the drug excretion rate vs. time is linear on a semilog scale and is parallel to the amount vs. time profile.

Slope = -k/2.303

The rate of drug excretion at any time divided by the corresponding plasma concentration is constant, and is equal to the total body clearance.

  • Page 2 of 2
  • 1
  • 2