Deterrnmation of the Pharmacokinetic Parameters

Deterrnmation of the
Pharmacokinetic Parameters

A, α, B and β are determined graphically. Since the distribution and the elimination processes are first-order, the half lives for these processes can be determined from:

Volume of the central compartment, V_c

The drug is distributed initially in the central compartment only.

Area under the curve, AUC

Integration of the equation that describes the plasma conc-time profile:

Total body clearance CL_T

The micro-rate constants, k₁₂,k₂₁ and k₁₀

While deriving the integrated equation, two different relationships are determined:

k₁₂ + k₂₁ + k₁₀ = α + β

k₂₁ k₁₀ = α β

First-order elimination rate constants, k₁₀

First-order transfer rate constants, k₂₁

First-order transfer rate constants, k₁₂

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Deterrnmation of the Pharmacokinetic Parameters

First order kinetics

Elimination half life

Area under the curve

Total body clearance (CLT)

Derivation of the integrated equation that describes the plasma conc-time profile

Deterrnmation of the
Pharmacokinetic Parameters

Total body clearance (CL_T)