Example: After administration of a single iv bolus dose of 100 mg lidocaine, the plasma conc-time profile can be described by the following expression
Cp (mg/L) = 2.6 e-5.0 t + 0.52 e-0.4 t
where t is in hours.
Calculate the following parameters:
Vc, AUC, CLT, k10, and Vdβ
The equation is in the form of:
Cp = A e-α t + B e-β t
This means :
A = 2.6 mg/L α = 5.0 hr-1
B = 0.52 mg/L β = 0.4 hr-1
Vc =
100 mg
2.6 mg/L + 0.52 mg/L
= 32 L
AUC =
2.6 mg/L
5.0 hr-1
+
0.52 mg/L
0.4 hr-1
= 1.82mg-hr/L
CLT =
100 mg
1.82 mg-hr/L
= 54.9 L/hr
k10 =
54.9 L/hr
32 L
= 1.72 hr -1
Vdβ =
54.9 L/hr
0.4 hr-1
= 137 L
