Examine the conc-time profiles after administration of the same dose over different duration, while keeping all other parameters constant.
|
Dose (mg) |
t'(hr) |
CLT(L/hr) |
V (L) |
200 |
1 |
3 |
15 |
|
Dose (mg) |
t'(hr) |
CLT(L/hr) |
V (L) |
200 |
1 |
3 |
15 |
Administration of the same dose over longer duration results in lower maximum plasma conc and higher minimum plasma concentration at steady state