Factors affecting the plasma
conc-time profile (cont'd)

b- Infusion time (t ')

Examine the conc-time profiles after administration of the same dose over different duration, while keeping all other parameters constant.

Parameters
Dose (mg) t'(hr) CLT(L/hr) V (L)
200 1 3 15
Infusion duration
Parameters
Dose (mg) t'(hr) CLT(L/hr) V (L)
200 1 3 15
Infusion duration

Administration of the same dose over longer duration results in lower maximum plasma conc and higher minimum plasma concentration at steady state

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