Factors affecting the plasma
conc-time profile (cont'd)

d- Volume of distribution (Vd)

Examine the conc-time profiles after administration of the same dose of a drug to different individuals who have different Vd. (all other parameters are constant)

Parameters
Dose (mg) t'(hr) CLT(L/hr) V (L)
400 1 3 15
Vd (L)

The s.s. conc is dependent on the dose and the total body clearance. Differences in Vd do not affect the s.s. drug conc.

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