Factors affecting the plasma
conc-time profile (cont'd)

c- Total body clearance (CLT)

Examine the conc-time profiles after administration of the same dose of a drug to different individuals who have different CLT ( all other parameters are constant)

Parameters
Dose (mg) t'(hr) CLT(L/hr) V (L)
100 1 1.2 25
CLT (L/hr)

Higher total body clearance leads to faster rate of drug elimination, and lower steady state plasma concentration.

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