Determination of the metabolite
pharmacokinetic parameters (Cont'd)

5- Metabolite area under the curve, AUC(m)

The metabolite AUC can be determined using the trapezoidal rule.

6- Metabolite formation clearance

The metabolite formation clearance is the fraction of the drug CLT that is responsible for the formation of the metabolite.

Formation clearance = fm CLT

7- Metabolite formation rate constant

It is the fraction of the parent drug elimination rate constant responsible for the formation of the metabolite.

Formation Rate Constant = fm k