Drug/metabolite profiles after iv
drug administration (cont'd).

d - Fraction of drug dose converted to the metabolite

Examine the drug and metabolite conc-time profiles after administration of the same dose of drugs that have different fm. (All other parameters are similar)

Parameters
D (mg) Vd (L) CLΤ(L/hr) fm CLΤ(m)(L/hr) Vd(m) (L)
1000 25 2 .2 1 10

0.2

fm

Detailed conclusion

Larger fm results in the formation of larger amount of the metabolite after administration of the same dose of drug.