- Administration of the same dose of different drugs that have similar CLT and Vd but different fm will produce similar drug conc-time profile and AUC.
- Administration of the same dose of drugs with increasing fm will result in a proportional increase in the amount of metabolite formed in vivo.
- Since the metabolite parameters are similar and the amount of metabolite formed in vivo increases proportional to fm and the metabolite AUC will increase proportional to the increase in fm
The amount of the metabolite formed after drug administration depends on the dose of the drug and fm. If fm is equal to unity (1) for a particular metabolite, this means that the entire dose of the parent drug is converted to that metabolite.
Drugs that undergo parallel metabolism to more than one metabolite have different fm values for each metabolite. The sum of these fm values should not be more than one, but it does not have to be equal to one (when the drug elimination involves a pathway other than metabolism).
This fraction should be dose independent when drug elimination follows first-order kinetics. Also, this fraction should not be different for a particular drug in a particular patient after different routes of administrations, if the metabolite is not formed during drug absorption after extravascular administration.