- Administration of the same dose of drugs with similar CL_T, Vd and f_m will result in similar drug conc-time profile, AUC, and the formation of similar amounts of the metabolites. Metabolites with higher clearance will be eliminated faster (Vd(m) is constant) and will have smaller AUC.

- When k(m) < k the metabolite conc declines at a rate dependent on k_(m) (elimination rate limited). While when k_(m) > k the metabolite conc declines at a rate dependent on k (formation rate limited).

The metabolite total body clearance is the volume of the plasma or blood which is completely cleared from the metabolite per unit time. It has units of vloume/time.

The CL_T(m) for the metabolite is constant within a patient (dose and concentration independent) when its elimination processes follow first-order kinetics.

The CL_T(m) is a measure of the efficiency of all eliminating organs in eliminating the metabolite.

The metabolite elimination rate constant and the metabolite half life (the dependent pharmacokinetic parameters) are dependent on (is determined from) the metabolite total body clearance and the metabolite volume of distribution (the independent pharmacokinetic parameters).