Steady State Concentration

c- Total Body Clearance

Examine the conc-time profiles after administration of the same dose of different drugs that have different CLΤ (all other parameters are constant).


OR

Examine the conc-time profiles after administration of the same dose of the same drug to different individuals with different function of the elimination organ(s) (different CLΤ).

Parameters
D (mg) F CLΤ(L/hr) Vd (L) ka (hr-1)
800 1 3.5 50 0.3
CLΤ (L/hr)

Higher CLT means higher rate of drug elimination (when Vd is constant) which leads to lower steady state plasma concentration